Granules

Granules are preparations consisting of solid, dry aggregates of powder particles sufficiently resistant to withstand handling. They are intended for oral administration. Some are swallowed as such, some are chewed and some are dissolved or dispersed in water or another suitable liquid before being administered.

 

Granules contain one or more active substances with or without excipients and, if necessary, suitable colouring and flavouring substances. They are mainly used for low-toxicity, high-dose drugs.

Aipak various types of granulation machine,with the granulation process, small fine or coarse particles are converted into large agglomerates called granules. And generally, the granulation commences after initial dry mixing of the necessary powder ingredients along with the active pharmaceutical ingredient (API), so that a uniform distribution of each ingredient throughout the powder mixture is achieved.

 

The granulation technique may be widely categorized in to two types, dry granulation and wet granulation, based on the type of method used to facilitate the agglomeration of powder particles . Dry granulation uses mechanical compression (slugs) or compaction (roller compaction) to facilitate the agglomeration of dry powder particles, while the wet granulation uses granulation liquid (binder/solvent) to facilitate the agglomeration by formation of wet mass by adhesion.

 

Aipak also provides sifter machine,bin mixer,bin blender,dry granulation machine,wet granulation machine and different models of dryer machine to make the granules good dosage form or be mixed with other excipients before tablet compaction or capsule filling.

Machines For Granules

Granulation Machine

HLSG Series High Shear Mixer Granulator

Model YK-160 Swing High Shear Mixer Granulator

FL Series Mixer Granulator Drier

KZL Series High Speed High Shear Mixer Granulator

Model ZL Rotating High Shear Mixer Granulator

GK Series Dry High Shear Mixer Granulator

GHL Series High Speed High Shear Mixer Granulator

Capsule Filling Machines

NJP-200C Capsule Filling Machine

NJP-400C Capsule Filling Machine

NJP-800C Capsule Filling Machine

NJP-1200C Capsule Filling Machine

NJP-1200D Capsule Filling Machine

NJP-2500C Capsule Filling Machine

NJP-3800C Capsule Filling Machine

NJP-5500C Capsule Filling Machine

NJP-7500C Capsule Filling Machine

CGN-208D Capsule Filling Machine

CGN208-D1 Capsule Filling Machine

CGN208-D2 Capsule Filling Machine

CGN208-D3 Capsule Filling Machine

CGN-208S Capsule Filling Machine

TM-100 200 250 Capsule Making Machine

RJN Capsule making machine

Tablet Press Machines

GZPS660 Tablet Press Machine

ZPW-4-4 Tablet Press Machine

ZP25 Tablet Press Machine

ZP5/7/9 Tablet Press Machine

Crusher Machine

GFSJ Series Crusher Machine

B Series Crusher Machine

WF Series Crusher Machine

YGJ Series Crusher Machine

DS Series Crusher Machine

WF Series Crusher Machine

Model B Series Crusher Machine

WCSJ Series Crusher Machine

WCSJ Series Dust Crusher Machine

WF Series Dust Crusher Machine

WCSJ Series Universal Crusher Machine

B Series Cyclone-separating Crusher Machine

CSJ Series Coarse Crusher

B Series Dust Collecting Crusher

GFSJ Series High Efficient Crusher

QS-100 Airflow Crusher

Model WF Series Crusher Machine

WFJ Series Dust Collecting Fine Crusher

YF Series Crusher Machine

WFM Series Super Crusher Machine

JCFJ Series Inner-Grading Mechanical Crusher

QLDJ Series Fluidized-bed Airflow Crusher

FYF Series Vegetables Crusher Machine

WFJ Series Dust Collecting Fine Crushing Set

JM Series Two-Stage Colloid Mill TAG

Bin Mixer

SWH Series 3D Motion Bin Mixer

GHS High speed Bin Mixer

Model CH-VI Forced-Type Bin Mixer

CH Series Tanker Typed Bin Mixer

Model EYH Series Bin Mixer

WSH Series Tank Type Bin Mixer

CH Series Typed Bin Mixer (2011)

WLDH- Horizontal Ribbon Bin Mixer

DLH Series Cone Bin Mixer

Model W Series Taper-shaped Bin Mixer

CW series stirring type Bin Mixer

Model CH-V Series Bin Mixer

Bin Blender

HDT Series Bin Blender

DTH Series Post Bin Blender

HGD Series Lab Bin Blender

Dryer Machine

FG Series Fluid bed Dryer

LPG Series High-speed Pharmaceutical Dryer

DW Series Mesh-Belt Pharmaceutical Dryer

ZLG Series Vibration Fluidized Bed Dryer

SZG Series Double Cone Rotary Vacuum Dryer

GFG Efficient Boiling Pharmaceutical Dryer

FL300 Pharmaceutical Dryer

GF Series High Efficiency Fluidized Bed Drier

FZG,YZG squar and round static vacuum dryer

Model RXH Series Pharmaceutical Dryer

Sifter Machine

ZS Series Sifter Machine

LXS Series Sifter Machine

ZS Vibrating Sifter Machine

ZS Series Screening Machine

Videos For Granules

See Aipak High Speed Powder Particle Food Crusher Machine

See Main Components of Aipak Pharmaceutical Crusher Machine

What Powder Mixed By Aipak Bin Blender?

How Granules Pressed By Single Punch Tablet Press Machine Into Tablets

How NJP-1200 Full Automatic Capsule Filling Machine Fills Granules

How NJP-800 Full Automatic Capsule Filling Machine Fills Granules

How Granules Pressed By Flower Type Single Punch Tablet Press Machine Into Tablets

Frequently Asked Questions

Granules can be classified into four types, effervescent granules, coated granules, gastro-resistant granules and modified-release granules.
Effervescent granules are uncoated granules generally containing acid substances and carbonates or hydrogen carbonates which react rapidly in the presence of water to release carbon dioxide. Coated granules consist of granules coated with one or more layers of mixtures of various excipients. The substances used as coatings (generally polymers) are usually applied as a solution or suspension in conditions in which evaporation of the vehicle occurs leaving a film of coating. Modified-release granules are coated or uncoated granules that contain special excipients or which are prepared by special procedures, or both, designed to modify the rate, the place or the time at which the active substance or substances are released. Gastro-resistant granules (also referred to as enteric-coated granules) are delayed-release granules that are intended to resist the gastric fluid and to release the active substance(s) in the intestine fluid.

Granules are produced to enhance the uniformity of the API in the final product, to increase the density of the blend so that it occupies less volume per unit weight for better storage and shipment, to facilitate metering or volumetric dispensing, to reduce dust during granulation process to reduce toxic exposure and process-related hazards, and to improve the appearance of the product.

Granules are designed to be taken with a small amount of food.

Sprinkle or stir the granules into a small amount of soft food (e.g. yogurt) or a small drink.

Your child should then swallow the food or drink straight away, without chewing. Make sure that they take it all.

You can also mix the granules with a spoonful of cold water and give it to your child to drink straight away, without chewing. Do not mix the granules with warm food or liquid.

Your child must take the granules within 15 minutes of opening the sachet. If the sachet has been open for more than 15 minutes, throw the contents away and use a new sachet.

Do not keep granules or a granule/food mixture to give later.

Granule is a related term of pellet.

As nouns the difference between granule and pellet is that granule is granule while pellet is a small, compressed, hard chunk of matter.

As verbs the difference between granule and pellet is that granule is while pellet is to form into pellets.

As an adjective granule is granulated.

Granules have smaller surface area than comparable volume of powder. Granules have smaller surface area than a comparable volume of powders. This makes granules more stable physically and chemically than the corresponding powders. Granules are less likely to cake or harden upon standing than are powders.

Granulation is the process of producing grains or granules. The size of a granule is typically in the range 0.2 – 4.0 mm. This term is often used in pharmaceutical industry since granulation is the process used in the production of tablets. There are three types of granulations as dry granulation, wet granulation, and direct blending. The main difference between dry and wet granulation is that dry granulation is the formation of granules without using any liquid solution whereas wet granulation is the formation of granules by adding a granulating liquid.

Helpful Resources For Granules

See High Shear Mixer

See High Shear Mixer: The Comprehensive FAQ Guide in 2021

Fluid Bed Dryer

Fluid Bed Dryer: Your Complete Solution Guide In 2021

Wet Granulation Machine

Wet Granulation Machine:The Complete Buying Guide in 2021

Interested In Purchasing Your First Granule Machines?

We have helpful resources to help answer common questions about granule machines, the most popular machines, and a helpful guidebook for first-time buyers.

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