High Quality Single Punch Tablet Press Machine

Meets GMP Requirement

All Stainless Steel Constructions

Reliable Safety Sealing System And Dust-Proof System

High Visibility Isolated Door To Prevent Cross-Contamination

AIPAK Tablet Press Machine

AIPAK tablet press machines have a wide application in the industry of pharmaceutical, chemical, food, electronic, etc.The tablet press machine is mainly for pressing powder or granule stuff into different shapes of tablet according production requirement, and also used for compressing biscuits for military and civilian use. Based on their state-of-the-art designs and technological innovations, AIPAK tablet press machines feature mature , stable running and durable quality. Along with these, they range from effervescent rotary tablet press machine to single punch tablet press machine and high speed high capacity rotary tablet press machine. With interchangeable turrets, producing annular, irregular or engraved tablets remains within the desired overall equipment efficiency . All AIPAK tablet press machines are GMP compliant and working stable ,safe and accurate with easy to operate and maintain.

tablet press machne-2
tablet press machne-1

AIPAK Single Punch Tablet Press Machine

TDP-1.5 Single punch tablet press machine

AIPAK TDP-1.5 single-punch tablet press machine is designed for pressing tablets from various granular materials,which is used for pharmaceutical,chemical,food, hospital,science research institution is applicable to trial manufacturing in lab or produce in small amount different kinds of tablet, sugar piece, calcium tablet and tablet of abnormal shape.It features a small desktop type press for motive and control sheeting.

Meets the requirements of GMP production

Precision machining

Efficient work

TDP-5 Single punch tablet press machine

AIPAK TDP-5 Single punch tablet press machine is a good machine designed for the lab used for research and for development in hospital and industry and for small-scale production.is used for pressing different kinds of granular raw materials into round tablets. It is applicable to trial manufacturing in lab or batch production in small amount different kinds of tablets, sugar pieces.

High precision filling

Low-noise & low-consumption

Adjustable tablet thickness

TDP-6 Single punch tablet press machine

AIPAK TDP-6 Single punch tablet press machine is a small desktop machine, easy to operate, driven by a motor can be continuously pressing tablets.The machine can be a variety of small particles, coarse powder pressing round or irregular tablets.It has the advantages of simple structure, convenient operation, high degree of automation, is suitable for various shaped tablet press.

Easy to operate

Simple structure& convenient operation

High degree of automation

DP12 single punch tablet press machine

AIPAK DP12 single-punch tablet press machine is used to press granular raw materials into tablets. It is widely applied for trial production and small batch production in pharmaceutical plants, chemical plants, food plants, hospitals,scientific research institutes and laboratories.With excellent performance, good adaptability, convenient use, easy maintenance, small volume and light weight.

Suitable for various shaped tablet press.

Hand -operated easy to be operated

Small volume& light weight

DP-25 single punch tablet press machine

AIPAK DP-25 single-punch tablet press machine is installed with only one set of punches, and the material filling depth and tablet thickness can be adjusted. Through the replacement of punches, tablets of different shapes and sizes can be made, so as to meet the needs for making various kinds of both dosmetic and western medicine tablets in the pharmaceutical industry and making various kinds of similar products in other industries. 

Custom mould

Portable &durable

Simple operation& easily repairs

AIPAK Flower Basket Tablet Press Machine

ZP-33 glass mosaic tablet press machine

AIPAK ZP-33 glass mosaic tablet press machine is used to press a variety of granular raw materials into a circular sheet, is suitable for mass production of the basic equipment, its structure is double pressure type, there are two sets of feeding devices and two sets of pressure wheels. The turntable can be equipped with 33 stamping dies, rotating for one week can press 66 pieces, the speed of the turntable, the filling depth of the material, and the thickness of the tablets can be adjusted.

Automatic refueling cup

Double layers can be pressed

Adjustable filling thickness

THP Flower basket tablet press machine

AIPAK THP Flower basket tablet press machine is a flower basket type continuous automatic tablet press, which is used in the pharmaceutical, chemical products, electronics and other industrial sectors to process granular raw materials into tablets.It is suitable for pressing pharmaceutical tablets, contact coal, pigment powder cake, mothballs, powder metallurgy, ceramic tablets, electronic components and various pesticide and fertilizer tablets in production, experiment, and testing departments.

Conforms to GMP standard

Produces large diameter tablets

Adjustable filling depth

THP-15 Flower basket tablet press machine

AIPAK THP-15 flower basket punching tablet press machine is used for pressing different kinds of granular raw materials into round tablets. It is applicable to trial manufacturing in lab or batch production in small amount different kinds of tablets, sugar pieces, calcium tablets and tablets of abnormal shape. It features a small desktop type press for motive and continual sheeting. It can also be hand-operated. Only one pair of punching die can be erected on this press. Both filling depth of material and thickness of tablet are adjustable.

Big pressure for big size tablets

Adjusted material filling and depth

Customizable dies

THP-I/II Flower basket punching tablet press machine

AIPAK THP-II flower basket punching tablet press machine is a small continuous automatic tablet press machine which is one of the essential equipments for pressing granular raw materials into tablets or medicines taken with water in pharmaceutical, chemical, food, electronics industries. It can be used to press medicinal tablets, catalysts, candies, caloium coffee pills, powder metallurgical parts electronics components, various tablets of pesticide and fertilizer etc.

Special mechamical structure

Excellent performance

Strong adaptability

AIPAK Rotary Tablet Press Machine

GZPB series automatic high-speed rotary tablet press machine

AIPAK GZPB series fully automatic high-speed rotary tablet press machine is is one kind of double side rotary tablet press machine, which can press granular materials into round shape tablet, irregular tablet or double-side engraved tablet. This machine is mainly used in Pharmaceutical, chemistry, foodstuff, electronic industries.it is made of stainless steel, the housing is fully closed. 

High speed&full automatic

Good performance&strong suitability

Adjustable thickness of tablets

HSZP-35 rotary tablet press machine

AIPAK HSZP series high-speed rotary tablet press machine is an economical high-speed tablet press machine and it is suitable for producing a great quantity tablets. It can be produced all types of round tablets, irregular tablets and tablets of engraved on double sides.The production capacity is large and the quality of production is better. It has pre-pressure device so that the time of pressure can be delayed.

Large power and pressure,Running smoothly

Overload protection unit

Frequency conversion device

ZP-13A Rotary Tablet Press machine

AIPAK ZP-13A tablet press machine is a single-press type, continuous automatic tablet press for pressing granular raw materials into tablets. It is sued for small-scale production.The machine is compliance with the GMP requirement on the production of pharmaceuticals.The compression parts is entirely separated from the driving mechanisms.

Frequency conversion device

Touch screen, easy to realize man-machine dialogue

Centralized Lubrication System

ZP-13B Rotary tablet press machine

AIPAK  ZP-13B tablet press machine is suitable for pressing round tablets form various kinds of granular materials, but also different geometrical shape tablet, specially for small-scale batch production. During operation, the speed of turret rotation, the depth of filling material and the thickness of the tablets can be adjusted. The pre-pressure unit and overload protection unit is included in the system.

Double-press type&continuously automatic

Compatible with the GMP requirement.

304 Stainless steel or 316 stainless steel

ZP15 17 19 Paint type rotary tablet press machine

AIPAK ZP15 17 19 Paint type rotary tablet press machine machine is is a GMP standard rotary single-sided press machine. It is an automatic machine working on granules or powder materials and press them into tablets. It is mainly used in pharmaceutical, chemical, food and electronic industries. The cover of this rotary tablet press is made of stainless steel with close type. 

Mould customization

Convenient&durable

Easy to operate

ZP-15A Rotary tablet press machine

AIPAK ZP-15A tablet press machine is a is a single-press type, continuous automatic tablet press for pressing granular raw materials into tablets. It is mainly used in pharmaceutical industry and also the chemical, food, electronic, plastic and metallurgical industries. The outside part of the machine is fully-enclosed, and it is made of stainless steel, meeting the G.M.P requirement.

Meet GMP requirement

Long service-life, preventing cross pollution

Easy cleaning and maintenance

ZP-15B rotary tablet press machine (forced feeding)

AIPAK ZP15B tablet press machine is can press not only round tablets but also different geometrical shape tablets, double-layer and annular tablets, and the tablets may have the impressed letters on both sides.All the controller and devices are located in one side of the machine, so that it can be easier to operate. An overload protection unit is included in the system to avoid the damage of the punches and apparatus, when overload occurs.

Design of GMP

High quality all stainless steel constructions.

Reliable safety sealing system

ZP-17B rotary tablet press machine(forced feeding)

AIPAK ZP-17B tablet press machine is a is complete. Besides producing the round shape tablets. It can also be produce irregular, ring shaped or double engraved tablets, it can not only produce single layer tables but also double; layers or even triple-layers ballets to satisfy the different dements of the customers.The machine is compatible to the GMP requirements.

High visibility isolated door to prevent cross contamination

Easily remove parts for quick machine's maintenance

High quality all stainless steel constructions

ZP-19A Rotary tablet press machine

AIPAK ZP-19A tablet press machine is a is convenient in operation and maintained.By adopting PLC programmable controller, the main functions, production data and malfunction of the tablet pressing are monitored and controlled. By adopting inverter for the speed adjustment, the adjustment of speed is step-less and reliable with a wide range.

Wide Application

High speed with large quantity punch

Perfect tablet pressing system

ZP21B rotary tablet press machine

AIPAK ZP21B rotary tablet press machine is double-press type,double outlets tablet press machine, it can make round, irregular medical tablet, sugar candy, calcium tablets, etc, by pressing granular materials.It is suitable for a wide range of production in large or small batches, mainly for the production of tablets in the pharmaceutical industry, but also in the chemical, food, electronics and other industries.

High performance

Electrical control system

Dust proof and noise proof design

ZP-33 Rotary tablet press machine

AIPAK ZP-33 Rotary tablet press machine is a single pressure automatic rotating, continuous tablet pressing machine, which presses the granular material into various tablets. It is mainly used in the production of tablets in thepharmaceutical industry, and is also applicable to chemical, food, electronic and other industrial sectors.

Conforms to GMP requirements

Perfect tableting system

High speed with large quantity punches

ZPS-8/10 Rotary tablet press machine

AIPAK ZPS-8/10 Rotary tablet press machine is a single-press type, continuous automatic tablet press for pressing granular raw materials into tablets. It is mainly used in pharmaceutical industry and also the chemical, food, electronic, plastic and metallurgical industries. It has transparent windows, so that press condition can be observed clearly and the windows can be opened.

Different geometrical shape tablets

Double-layer and annular tablets

Easy to operate

ZPW-15D/17D/19D Rotary tablet press machine

AIPAK ZPW-17D Rotary Tablet Press machine is single press type, continuous automatic tablet press for pressing granular raw materials into tablets.It is compliance with the GMP requirement on the production of pharmaceuticals.The compression area is enclosed with transparent organic glass. To prevent contaminates. The compression area can be specially treated.

Overload protection unit

Long-service life

Meeting the GMP requirement

ZPW21B Rotary tablet press machine

AIPAK ZPW21B Rotary tablet press machine is with good performance, strong suitability, simple operation, easily repairs, small cubage and light. Even under the conditions or power cut, hand swing available. It is only with one set of die, the depth of filling and the thickness of tablets is adjustable.It is made of stainless steel, the housing is fully closed. 

Easy to operate and maintenance

Running stably and durably

Wide application

ZPW-21/23 Three-color tablet press machine

AIPAK ZPW-21/23 Three-color tablet press machine is high speed with large quantity punches, double press rollers, suitable for mass production.Its double impeller type force feeder, improve granules flow-ability and filling performance, ensure the filling precision.It has perfect tableting system, twice compression forming.

Easy for operation

Stop automatically in case of overpressure

Easy cleaning and maintenance

AIPAK High Speed Tablet Press Machine

High speed high capacity GZPS660 series rotary tablet press machine

High speed high capacity GZPS660 series rotary tablet press machine is one kind of double side rotary tablet press machine, which can press granular materials into round shape tablet, irregular tablet or double-side engraved tablet. This machine is mainly used in pharmaceutical, chemistry, foodstuff, electronic industries.

High speed

Conforms to GMP requirements

Suitable for Mass production

China unique ZPW-4-4 Rotary Block Press (compressed biscuit making machine)

This rotary tablet press is a type of food machinery, which is used to produce compressed biscuits for military and civilian use. Compressed biscuit production involves five main processes, that is, biscuit baking, powderizing, mixing, compressing and packaging. The rotary tablet press plays an important role in making compressed biscuits.

Mechanical Structure

Hydraulic System

Electric drive unit and electronic control unit

ZP25 effervescent rotary tablet press machine for Pharmacy

ZP25 effervescent rotary tablet press machine is a latest rotary tablet press developed by our company,used to press granular raw materials into tablets.It is the only professional effervescent tablet press in china.It is mainly used for tablet production of effervescent tablets,aromatic tablets,washing blocks and other tablets with difficult mold release.

Conforms to GMP requirements

Easy cleaning and maintenance

Variable Frequency Speed Adjustment

ZP5/7/9 Top Quality of Single Punch Tablet Press Machine

ZP5-7-9 rotary tablet press is mainly used in the tablet technology research of the pharmaceutical industry. The granular material is pressed into a circular shape with a diameter of not more than 18mm, and the automatic continuous with the text, symbol and graphic sheet. Production equipment. The compressed flake material is a granule containing no more than 10% of powder (100 mesh or more).

GMP compliant

Reasonable Structure

Low Nosie

Tablet Press Machine Videos

The Buyer's Guide

Tablet Press Machine:the Ultimate Buying Guide in 2024

Tablet is a kind of widely used dosage form and as its simple taking and convenient carrying that makes it more and more favored by people nowadays .

While as its “founder”, the tablet press machine can’t be denied.

Yes,as a fundamental equipment in pharmaceutical machinery,tablet press machine has played an integral role in today’s world and been an dispensable device in pharmaceutical,chemical,food,daily goods and other industries.

Some of you may begin to ask what is that magical tablet press machine.

So today I am going to take advantage of this tablet press machine ultimate buying guide to introduce some of the benefits,classifications,parts,working principle,installation and FAQ about this machinery.

You may make your desired pill or become a professional from a beginner by investing in a suitable tablet press machine.

Now,let’s go straight to the main subject of this guide:

    Add a header to begin generating the table of contents

    1.What is a Tablet Press Machine?

    A tablet press machine also referred to as a tabletting machine,tablet compression machine,tablet punching machine,tablet making machine or pill press machine.

    It is mechanical device that compresses various granular materials into uniform shape,size and weight of tablets.

    While the quantity of active pharmaceutical ingredient (API) and excipients after compression containing are approximately the same.

    Various-compressed-tablets

    Various compressed tablets

    With the technology innovation that makes the development of tablet press machine a continuous process,as in the past,we have hand-driven mechanical tablet press while nowadays it has been modernized to electrical driven tablet press.

    Aipak-tablet-press-machine-2

    AIPAK Tablet press machine

    And all tablet press machine owns the same basic principle of compression and its basic unit is tooling consist of two punches and a die called station.

    The upper and lower punches come together in the die that makes the tablet formulation.

    2.What materials can be compressed into tablets using a Tablet Press Machine?

    You can compess a wide range of granule or powder materials into tablets using a tablet press machine.

    Below you will find the materials you can easily press to tablets:

    • Pharmaceutical Products
    • Cosmetic Products
    • Cleaning and Sterilizing Products

    Chlorine-Dioxide-Disinfectants-Tablets

    Chlorine Dioxide Disinfectants Tablets

    But you will need to take note for the name of the machine which determines the specific purpose when choose a tablet press machine.

    3.Where are the applications of a Tablet Press Machine?

    You can use a tablet press machine to make different shapes of tablets for different purposes.

    You will find the various industries include:

    1.Pharmaceutical Industry

    Pharmaceutical industry is one of the industries related to national economy and people's livelihood.

    Tablet press machine in this industry is used to make different functional medical tablets with different formulations of active ingredients for different disease treatment options.

    In addition,you can also use the tablet press machine to make the traditional medicine tablet and western medicine tablet.

    2.Food Industry

    You can the tablet press machine to make confectionaries,compressed biscuits and food supplements, like chicken essence block, isatis root block, divine tea block,etc.

    Compressed-biscuits

    Compressed biscuits

    3.Military industry

    It may rare to you for the military industry,in fact, tablet press machine in military industry is a type of food machinery, which is used to produce compressed biscuits for military and civilian use.

    Aipak-compressed-biscuit-making-machine

    AIPAK compressed biscuit making machine

    Compressed biscuit production involves five main processes, that is, biscuit baking, powderizing, mixing, compressing and packaging.

    4.Chemical Industry

    You will easily find some chemical substances are in tablet in your daily life like the disinfection tablets.

    Chlorine-dioxide-disinfection-tablet

    Chlorine dioxide disinfection tablet

    You can use a tablet press machine to compress different kinds of chemical granules and powders into tablets,such as camphor pills, health balls, washing blocks, the smurfs blocks, art powder, pesticide tablets, etc.

    5.Cosmetics Industry

    Cosmetics Industry prefers to use tablet press machine to make tablets for use of enhance beauty.

    That is,you will use the tablet press machine to make different sizes,shapes and colors of beauty tablets.

    6.Healthcare Industry

    You can use the tablet press machine to produce different forms of healthcare supplement tablets.

    Like the pharmaceutical industry,different formulations of active ingredients are been compression to play the health care function,such as the effervescent vitamin C.

    4.What shapes of tablet can you produce using a Tablet Press Machine?

    You can produce a wide range shapes of tablets using a tablet press machine as to the variations of the tooling system,which determines the final shape of the tablet.

    shape-of-the-tablet

    Generally,the most commonly shapes include:

    • Round shapes
    • Cylindrical shapes
    • Spherical shapes
    • Concave shapes
    • Convex shapes
    • And other geometric shapes (such as square, triangle, ellipse, capsule, etc.) can also be pressed with words, trademarks, patterns on them.

    5.Why need a medicine in tablet dosgae form?

    Everyone knows,pharmaceutical industry is somewhat a board industry.

    That means people could get different forms of dosage when they are taking various treatments or other similar conditions.

    However,from time immemorial,tablets dosgae form seem to be favorred by people.

    Someone-is-taking-tablets

    Someone is taking tablets-Photo Credits:Healthline

    It is one one of the significant forms,on the one hand,it is most popular solid forms for drug delivery.

    On the other hand,as a mixture of active ingredients and excipients,the essence of tablet dosage form is to enhance or prompt the treatment plan for a certain condition.

    Well,we can see that tablets have a lot of functions especially when reaching a certain dosage.

    In fact,there are many benefits that tablet dosage form will bring to you.As for the reasons,I would like to explain in details.

    1.Cover bad taste

    A patient will be more acceptable and accessible to tablet as it has covered the bad taste of drugs.

    The situation is in order to get rid of the bad taste of some substances,some drugs are manufactured to be bitter and generally have a bad taste,while the patients always find it difficult to swallow.

    But for compressed tablet,it won’t be as its concentrated ingredients.

    2.Accurate measurement

    When you are sick,the physician will prescribe medicines for you,and will instruct you to take according to a certain amount,and in order to get better as soon as possible,you will certainly follow the exact instruction.

    That is ,most of the circumstance,tablets will provide the most precise dosage that contain certain meaningful substance.

    3.Easy formulation

    Take the same case for example,when you are sick,you may need to take different kinds of medicines at the same time,this is because you may need the two or more compounds to act on different functions.

    And in order to avoid the many times’ taking medicines,the manufacturers formulate all the medicines into one substance,of course,there is no conflict for the formulation.

    Easy formulation

    Tablet form

    Besides,just like a capsule,drugs in tablet dosage form also helps in covering up the flavor of substance that doesn’t taste good.

    4.Easy for identificating

    You may have heard the cases of wrong prescription of drugs to the patients in the pharmaceutical world.

    The main cause of this confusion is that the physicians is hard to identificate the same medicine,let alone the novices.

    In fact,sometimes,some different forms of drug dosage may have similar final products or have little variations that make them difficult to distinguish.

    Various-tablets

    Various tablets

    While,not to mention that some patients need to differentiate the drugs after backing home.

    But with the tablets which make the drugs easy to be identificated as they are produced with various colour coated or embossed marking.

    5.Stable dosage

    Compare with other types of dosage form,tablet form is relative stable as its chemical,physical properties are better .

    What’s important,you can also manage the dosage to your treatment when you are using this type of dosage.

    6.How many types of Tablet Press Machines are there?

    Tablet press machine in current use can be classified into:

    Single punch press machine

    Aipak-single-punch-tablet-press-machine

    AIPAK single punch tablet press machine

    It also known as single station press machine which contains a single set of station tooling (a die and a pair of upper and lower punches).

    It is the simplest device that manufacturing tablet as it can be either hand operated or mechanically driven.

    It works by the compaction force on the fill material exerted by the upper punch while the lower punch is static.

    And such action is equivalent to hammering motion, and as a result, the single punch press is referred to as stamping process.

    The single punch tablet press produces about 60-85 tablets/min,suitable for laboratory and large-scale tablet production.

    Muti-station rotary tablet press machine

    It is either a mechanical or an electrical device that has several tooling stations which

    rotates to compress granules/powder mixture into tablets of uniform size, shape (depending on the punch design) and uniform weight.

    It was developed to increase the output of tablets and has a range of types,can be customized to meet specification production requirements.

    Aipak-effervescent-rotary-tablet-press-machine

    AIPAK effervescent rotary tablet press machine

    During the working of rotary press, the compaction force on the fill material is exerted by both the upper and lower punches leaving the powder granules to be compressed in the middle.

    This is also the so-called accordion type of compression.

    The capacity of a rotary tablet press is determined by the rotation speed of the turret and the number of stations on the press.

    And as the technological process of the rotary press is continuous, continuous feeding and continuous discharging,and in terms of the whole machine, the force is relatively uniform and stable, it is widely used in the formal production.

    Flower Basket types tablet press

    This machine is used to press medicinal tablets,coffee pills,powder metallurgical parts,electronic components,various tablets of fertilizer.

    It is suitable for small-batch production in labortary and hospital.

    Flower-Basket-types-tablet-press

    Flower Basket types tablet press

    7.How does a Single Punch Tablet Press Machine work?

    The working steps of a single punch tablet press machine can be described as follows:

    Filling

    1.The upper cam will withdraw the upper punch from the die, the lower punch will be low inside the die cavity to make the granules fall from the hopper and fill the cavity made by the die and the lower punch.

    2.You shall adjust the weight of the material to be required by the lower punch and when the lower punch lifts, the excess of powder will be ejected from the die.

    Compression

    3.The lower punch remains stationary and the upper punch will down to the die to compress the powder into a tablet.

    Single-Punch-Tablet-Press-Machine

    Ejection

    4.The upper punch is then withdrawn while the lower punch pushes upwards lifting the formed tablet from the die. The tablet is then removed from the die surface by the surface plate.

    5.Then repeat the cycle in the next batch.

    And during the production,you will need to manually adjust the machine to suit the type of tablet, the material, compression and capacity of material required for each tablet.

    While through that step you can also make a check on the appearance, size and mechanical robustness of the formed tablets.

    Once you are satisfied with the quality of the tablet, the mechanical adjustments will be  locked into place, and the machine is ready for automatic production.

    So,to maintain the quality and standard of the product,you will need regularly check the setting especially if you need to make large quantities of tablets.

    8.What are the functional parts of a Single Punch Tablet Press Machine?

    functional-parts-of-a-Single-Punch-Tablet-Press-Machine

    Hopper

    It is connected with the feed shoe and the part where the granules/power mixtures are poured into before the compression process.

    It can be filled manually or by using mechanical equipment during the during the subsequent pressing process.

    Die cavity

    It is the places where the granules/power are compressed into tablets.

    While the die cavity also determines three aspects of the tablets,namely:

    1.The size of the tablet

    2.The diameter of the tablet

    3.The thickness of the tablet

    Punches

    There are the the upper and the lower punch that united to compress the power into tablets of various shapes within the die.

    Cam truck

    This part is to regulate the position or movement of the upper and lower punch.

    Ejection adjuster

    It is the part that facilitates the ejection of the tablet from the die cavity after compression.

    Tablet adjuster

    It is to adjust the volume of the power to be pressed then determines the weight of the tablets.

    9.What are the advantage of using a Single Punch Tablet Press Machine?

    Single punch tablet press machine is widely used in pharmacy, chemical, food, hospitals, scientific research units, lab trial production and small batch production,so you will find its advantages are:

    1.It is small with rational structure that won’t take too much space and easy to move.

    2.The single punch works at a high utilization ratio and it is easy for your operation with all kinds of dies can be customized and installed.

    Easy-pressure-adjuster-of-single-punch

    Easy pressure adjuster of single punch

    3.You can use it to manufacture odd-shaped tablets which will be more attractive to your customers since both the material filling depth and sheet thickness can be adjusted.

    4.Each piece made by the single puch are even with the same hardness as the machine utilizes a high amount of pressure to reduce the weight variations between them.

    5.It can hand-cranked even there is no power supply.

    6.It won’t produce too much noise during the compression process.

    10.Is there any disadvantages of a Single Punch Tablet Press Machine?

    Yes,just like any other machines,a single punch tablet press machine its disadvantages in using.

    Comparing with any other types of tablet press machine,it is slower in speed.

    Besides,it is a little hard for you to clean the single punch tablet press machine some of its parts are exposed to the air.

    11.How does a Rotary Tablet Press Machine work?

    Like the single punch tablet press machine,a rotary tablet press machine will go through three main steps to make a tablet which include:

    Filling

    Firstly ,you will need to fill up the hopper with granules or the to compressed raw materials when the machine is running.

    Processing the materials

    Then the materials will go through various procedures from the hopper that include:granulation,dressing and other types of processing projects.

    Besides,the rotary tablet press machine will also mix the granules to make them become homogenous mixtures.

    Compression

    The mixed granules will flow into die cavity from the hopper to be compressed.

    Then when the die cavity is fully filled,you will need to gauge the number of granules by removing the excess of granules,through which the machine will compress the appropriate volume of granules into tablets.

    Then the lower and upper punch will begin to work to compress the granules into various shapes and sizes of tablet you want.

    Ejection

    This step the machine will remove the punch from the die cavity by the lower punch,and the upper punch will retract from the die cavity by lifting above the turret.

    Then the lower punch will lift upwards by pushing the tablets out from the die cavity.

    Among which procedure,the eject cam will affect the ejection of the tablets from the die cavity.

    Finally,you shall take off the blades and the compressed tablets will be removed from the die cavity for the next process.

    12.What are the main components of a Rotary Tablet Press Machine?

    A tablet press machine is basically made by the hopper, dies, punches, cam tracks and feeding mechanism,while for a rotary tablet press machine,it consists of more parts than that of the single punch.

    main-components-of-a-Rotary-Tablet-Press-Machine

    Now,let's talk about them in details.:

    1.Hopper

    Feeding-Hopper

    Feeding Hopper

    A hopper is basically the feeding station of the rotary tablet press machine.

    From where you will put the granules/power mixture that are to be compressed into tablets.

    2.Die cavity

    Just like the single punch,the die cavity is the most critical place for the tablet making process as it is where the granules/power are compressed into tablets.

    The shape of die system is also determined by many factors such as the tablet diameter, size and thickness, other features such as logos where necessary.

    3.Feeding paddle

    This part help to force the feeding of granules or powder mixture into the dies especially during quick rotation.

    Feeding paddle

    4.Punches

    As the single punch,the rotary tablet press machine is also comprised by upper and lower punch,which move within the die bore to compress the granules into tablets.

    5.Cam tracks

    To guarantee the normal movement of both the upper and the lower punches,there need the cam tracks.

    6.Lower cam track

    During the filling stage,the lower cam track will guide the lower punch to make in time adjustment when the die bore is overfilled .

    7.Ejection cam

    This part is used to facilitate the ejection of the compressed tablets from the die cavity by guiding the lower punch go upwards.

    8.Depts of fill/capacity control

    It is to ensure the appropriate quantity of granules remain in the die before the compression process by adjusting the lower punch track during the latter section of the filling stage.

    9.Pre-compression rollers

    There might be excess of air entrapped in the die,then the pre-compression rollers are to drive the granules to give them an compression force to get rid of this air.

    10.Main compression

    It is the part that dives the final compression force needed for the formulation of the tablets.

    11.Take-off blade

    The blade is located in front of the feeding house and it is for deflecting the compressed tablets down the discharge chute.

    12.Discharge chute

    This is the place where the compressed tablets pass through for collection after being deflected by the take-off blade.

    13.Operation panle

    Operation-panle

    This part includes the emergency switch and you can use it to control the thickness and pressure during the tablet compression process.

    13.What are the advantages of using a Rotary Tablet Press Machine?

    Rotary tablet press machine is mainly used in pharmaceutical industry and the chemical, food, plastics, powder,metallurgy and electronic industries.

    Aipak-effervescent-rotary-tablet-press-machine

    AIPAK rotary tablet press machine

    You only need to replace components and adding powder absorbing apparatus which greatly lowers the cost .

    While,apart from that,you will also find so many advantages of tablet press machine including:

    • You will gain high productivity with minimal amount of labour at the same time saving money.
    • You will have decrease of waste of valuable substance which will have in non-specific tablets.

    Various-tablets-by-the-rotary-tablet-press-machine

    Various tablets by the rotary tablet press machine

    • You are allowed to control either the weight or hardness independently.
    • Your powder-filled cavity can be automatically managed by a moving feeder.
    • You will have a large output that up 9000-234000 pieces per hour which will not only save your time but also meet up with the high demand of tablet dosage form.
    • There is high visibility isolated door that help you prevent from cross contamination.
    • The 360°design makes it easy for your observation and cleaning.

    14.Is there any disadvantages of using a Rotary Tablet Press Machine?

    A rotary tablet press machine has large output but also has its demerits.

    First,a rotary tablet press machine is large in size and has heavy weight,which will make it difficult for you to move the machine from one place to another.

    The cost of purchasing and installing the machine is much higher,you will need to have large output profits to balance which.

    You will also need to train your workers to be familiarly operating the machine that will also add to your cost.

    The machine will also lead to environment pollution as it will release some wastes by the some substances through the compression .

    15.What are the differences between a Single Punch Tablet Press Machine and a Rotary Tablet Press Machine?

    In fact,there are many variations between a single punch and rotary press machine from tablet press technological process,tablet press procedure to the tablet quality,etc.

    The tablet is better from the rotary press machine than the single punch while the operation procedures are more complicated.

    But the four most important differences you will find are:

    1.The single punch tablet press adopts single-sided compression to make tables while the rotary tablet press utilizes double-sided compression.

    2.There is no dwell time during the compression cycles of single punch tablet press whereas the rotary tablet press uses a punch head flat that enables a dwell time when the punch go through under the compression roller.

    3.The exhaust ability of the single punch tablet press machine is poor than that of the rotary tablet press machine after the granules or powder are compressed.

    4.The flowability of the granules is not visible to you for a single punch while the rotary press is.

    16.What is the tooling in Tablet Press Machine?

    Tooling is the basic mechanical elements of whatever tablet press machine.

    It is made by the die and its associated punches,who are essential tools in the tablet compression process.

    They are also what key elements that determines the design and functions of the tablet press machine.

    Besides,these punches and dies are critical to the quality of the tablet produced like the size,shape and nature.

    Generally,a standard punch consists of three parts:the upper punch and lower punch whose working makes the surface shape of the tablets.

    Tooling-system-of-the-tablet-press-machine

    Tooling system of the tablet press machine

    The working the upper and lower punches that makes the surface shape of the tablets.

    According to the structure and shape of die, it can be divided into circle and special shape (including polygon and curve).

    The shape of the the punch can be plane, hypotenuse, shallow concave, deep concave and comprehensive.While the plane shape and hypotenuse punch are used to press flat cylindrical tablet, shallow concave shape is used to press double convex tablet, deep concave shape is mainly used to press coated tablet chip, and comprehensive shape is mainly used to press special-shaped tablet.

    press special-shaped tablet

    Different shapes of tablets

    In order to identify and take medicine easily, you can also engrave the name, dosage and vertical and horizontal lines of medicine  on the the die.

    Therefore,you will need to select the appropriate types of tooling to compress different size or shape of tablets.

    17.What are the commonly used tablet press tooling?

    Tablet press tooling can classified into “B”,”D”, “BB”,”DB” types,you will find the difference of tooling configurations between the four types are:

    working-of-tablet-punching-machine

    While the most commonly used types are:

    • ”B” type
    • ”D” type

    They are counted as the majority of tooling configuration used today.

    ”B” type

    From above image you can see that the “B” type configuration has a normal punch barrel diameter of 0.750 inches that is 19mm.

    It can be used with two types of die or with two different sizes of die that including:

    1.Die with a diameter of 1.1875 inches,that is 30.16mm,which is suitable for all sizes of tablets up to the maximum for its “B” punch.

    2.Small “B” die that has a diameter of 0.945 inches,that is 24mm,and the die type is suitable for tablets with a diameter up to 9mm or the maximum to 11mm.

    ”D” type

    The “D” type tooling has a larger barrel diameter of 1 inches,that is 25.4mm and a die diameter of 1.500 inches,that is 38.10mm,which is suitable for tablets with a maximum diameter or maximum length of 25.4mm.

    Besides,you will need to know that the “B” and “D” type only can be used separately.

    And the compression force used in the tablet press machine depends on the type of tooling used.

    That is,a tablet press machine with “B” type tooling can exert a maximum compression force of 6.5 tones while the “D” type can exert 10 tones.

    Surely,there are some specially machines that are designed with exerting higher compression force,you can control the size of the punch tip or choose the special design.

    Last but not the least,you can achieve higher output through the following aspects including:

    1.Increase the number of effective punches

    2.Increase the number of station

    3.Increase the number of compression points.

    4.Increase the rate of the compression turret speed.

    Of course,they are not absolute and have their limitations and advantages.

    18.What aspects do you need to consider for choosing the suitable Tablet Press tooling?

    From the above introduction,you may have a general impression that your ideal tablets are determined by the type of tooling system.

    While considering all the tooling option and steel types available on the market now,you will be still confused and complicated to choose the most suitable tablet tooling,I would like to give my advise before you make the final decision.

    Firstly,you may need to request the supplier to provide a tool and tablet drawing for approval,actually,most tooling manufacturers can provide a sample of copper or other special materials made tablets to you.

    Secondly,I also would like to give you a guideline list that you need to request the tooling manufacturers to provide to you for further approval to meets the special requirements of your tablet press.

    1.The press type, model number, and number of stations.

    2.The size, shape, and cup depth of the tablet to be compressed,otherwise a sample tablet or sample tools would be enough.

    3.Drawing number of the tablet if they have a drawing.

    4.Historical data of tablet problems such as capping, sticking, picking, high ejection forces, etc..

    5.Special options such as tapered dies, domed heads, key type, etc.

    6.If have special shipping instructions

    19.What do you need to consider when choosing the material for an Effervescent Tablet Press Machine?

    Effervescent tablet press machine is a kind of automatic rotating and continuous tablet press machine.

    Aipak-effervescent-rotary-tablet-press-machine

    AIPAK Effervescent tablet press machine

    It is also a special equipment for chemical, food, electronic and other industrial enterprises to press granular raw materials into tablets or granules, which is suitable for small batch production.

    At present, the effervescent tablet press on the market can press all kinds of special-shaped, circular and double color tablets, and can press tablets with trademark, text and simple figure on both sides.

    It is equipped with overload protection device. When the pressure is overloaded, it can automatically shut down.

    This kind of tablet press improves the uniformity of tablet density and reduces the phenomenon of split and loose tablets.

    Generally speaking, a reasonable materials selection will achieve satisfactory effect,yo will need to pay attention to the following items.

    Fluidity

    The materials needed for the effervescent tablet should have good fluidity and be easy to flow into the mold hole evenly to fill a certain amount.

    At the same time, it also needs to have a certain viscosity, so that the pressure can form a tablet, but it can not be too sticky, or it will be difficult to demould.

    Hygroscopicity

    The hygroscopicity of materials should not be ignored.

    For example, sugar powder is easy to absorb moisture, which will make the effervescent tablet soft and deliquescent.

    Effervescent

    Effervescent

    Adhesive

    The selection of adhesive has a great influence on the quality of finished products.

    If the viscosity is not enough or the dosage is too little, the pressed product is easy to loosen and break, but if the viscosity is too strong or the dosage is too much, the particles will be too hard, and the effervescent tablet sugar made is not easy to dissolve or disintegrate. Syrup is a kind of adhesive with strong viscosity, and the made sugar tablet are hard.

    When you are using dextrin as adhesive, if the amount is too large, the particles will be too hard, and the surface of the extruded sugar tablet often has spots and pockmarks, which will affect the disintegration speed of the effervescent tablet.

    Acid and alkali materials

    Acid and alkali materials have certain influence on effervescent effect and production.

    There are three point that you need to consider:

    First, the proportion of acid and alkali materials plays an important role in the effervescence effect.

    Generally, the carbon dioxide content in the finished product is not less than 8%. In order to make the product moderate in sour and sweet, and ensure that the neutralization effect of bicarbonate or carbonate is complete, the consumption of acid is generally slightly higher than that of alkali by 10%.

    Second, if citric acid must be used in the formula, the humidity and temperature of the production workshop must be controlled within the recommended humidity temperature, otherwise it will stick the punch.

    Third, the citric acid was replaced by tartaric acid or fumaric acid, the effect was better without precipitation.

    Tartaric acid instead of citric acid, moisture absorption will be greatly reduced, but the taste is not as good as citric acid.

    Magnesium stearate

    It is understood that magnesium stearate is mostly used as lubricant in the process of tablet pressing, but all raw materials and auxiliary materials for making vitamin C effervescent tablets should be soluble in water, because magnesium stearate is hydrophobic and insoluble in water, and the use of magnesium stearate in vitamin C effervescent tablets will produce turbidity and precipitation, so it is recommended not to use or use as little as possible.

    20.What is the turret of Tablet Press Machine?

    Turret is the key parts of a tablet press machine as its holes hold the dies of the machine and ensure the correct alignment of the die packets and the punch guides.

    turret of Tablet Press Machine

    Turret

    Generally,the turret in a tablet press machine contains three critical parts.

    • Die turret which holds the dies.
    • Upper turret which hold the upper punches
    • Lower turret which holds the lower punches

    21.Which support equipment do you need for the tablet compression?

    To make a tablet,except the tablet press machine,you will also need some supporting equipment,they are:

    1.A dust collector

    It is a dedusting device that helps to get rid off the excess dust from the tablet press machine.

    2.High shear mixer machine

    You will need this machine to make the even,quick and easy mixture of the tablet formulation ingredients.

    A-high-shear-mixer-machine

    A high shear mixer machine

    3.A granulator

    A granulator will help in the forming of the tablet.

    4.A metal detector

    This metal detector is to inspect the metal fragments within the compressed tablets.

    5.A tablet coating machine

    You will need a coating machine to coating the formed tablets.

    6.A fluid bed dryer

    It is a drying machine that is used to dry the wet granules.

    A-fluid-bed-dryer

    A fluid bed dryer

    7.Weight checker

    This weight checker is used for weighting the tablets and reject tablets that exceeded the weight tolerance.

    22.What are the GMP requirements for Tablet Press Machine?

    GMP refer to good manufacturing practice,which is a standard requirement that the tablet press machine must meet,as it will guarantee the safety and hygiene of the tablet manufacturing.

    But also certifies the machine is made by qualified material that will not contaminated your products.

    Besides,a tablet press machine that meet with GMP standard will also guarantee your manufacturing is consistent and can be controlled according to required quality standards.

    To be concluded,meet the GMP requirement will help you minimize the production risks which can’t be reduced by testing the final product.

    GMP-requirements-for-Tablet-Press-Machine

    Then you what are the GMP requirements for the tablet press machine.

    Here there is a list .

    1.Design requirements for tablet pressing equipment

    i.Equipment selection

    1) It should have the functions of dust collection and cleaning.

    2) The operation is convenient and reliable, and there is necessary adjustment device. Such as mechanical adjustment device, filling adjustment device, pressure adjustment device, speed adjustment device, sheet thickness adjustment device, etc.

    3) It should have reliable safety protection function. Such as pressure overload protection, and current overload protection.

    Some equipment with high degree of automatic control also has the functions of breaking protection, scraping out, fault alarming, automatic weighing and testing, etc.

    4) The design of the tablet pressing chamber shall meet the requirements of airtight (isolated from the outside), no pollution, no dead angle, easy to observe, easy to clean, easy to assemble and disassemble the mould, etc.

    5) It should have a protective device to prevent injury to human body. Such as grounding device, over-current breaking protection device, automatic opening breaking protection device, etc.

    6) The design is beautiful and simple, easy to operate, observe and maintain.

    ii.Determination of performance parameters

    1) It shall meet with the national or industrial standards.

    Formulate enterprise product standards that are stricter than national or industrial standards, and actively promote the adoption of international standards, such as EU standards and IPT standards for tablet dies.

    2) Good sealing and isolation measures.

    For example, the sealing and isolation between the mechanical components and the tablet pressing chamber, the sealing and isolation between the punch body (the up and down movement guiding role) and the punch top (the part contacting with the material), the sealing and isolation between the upper and lower parts of the turntable (the punch body guiding role) and the middle worktable (the area of material flow and tablet forming), the sealing and isolation between the tablet pressing chamber and the outside, etc.

    3) Good mechanical properties.

    The transmission is stable, with appropriate accuracy, low noise, no obvious vibration and abnormal thermal deformation.

    iii.Management of technical documents

    1) There is a complete set of technical documents and quality records that meet the national standards, and the requirements of equipment manufacturing, installation and operation combined with the actual situation of the enterprise.

    a) In the equipment selection stage: there are documents and records such as information collection, market research, technical investigation, feasibility analysis, development decision-making, etc.

    b) In the stage of equipment design: there are documents and records such as product design scheme, technical and economic cost analysis, design calculation, design verification, structure and component design, process design, etc.

    2) Establish document control files, standardize management, and ensure the operation quality and traceability of the design system.

    2.Manufacturing requirements for tablet pressing equipment

    i.Purchase

    1) Establish purchasing quality control files, select qualified and reputable suppliers to ensure purchasing quality.

    2) According to the requirements of the procurement documents, purchase the raw materials and all kinds of materials that meet the quality requirements and have the quality assurance certificate or qualification certificate.

    3) Carry out necessary material chemical analysis for main key parts and raw materials with GMP requirements.

    4) Carry out incoming inspection and quality tracking for important standard parts and accessories.

    ii.Manufacturing

    1) You can assemble,debug the parts and manufacturing according to the design drawings, process documents and relevant standards.

    2) Set up processing quality control points for the manufacturing of main key parts and standardize the construction.

    3) Strengthen the quality inspection of parts manufacturing with GMP requirements to prevent mixing and knocking.

    4) Necessary quality control is carried out for the surface coating process of some parts required by GMP to prevent coating peeling and rusting.

    3.Installation requirements of tablet press machine

    The manufacturer shall prepare the operation manual of the equipment, including: composition and use of the machine; technical parameters; transportation, installation, storage; operation and adjustment; maintenance; catalog of vulnerable parts, and shall be obliged to help and guide the user to install and use the equipment.

    You can install the equipment according to the installation method and requirements in the operation manual.

    The installation environment of the equipment shall meet the relevant provisions of the pharmaceutical production quality management code (1998 Revision).

    Necessary auxiliary facilities shall be provided, such as power supply, compressed air source, feeding device, dust removal device, etc.

    The equipment shall be operated in air or in test run to confirm the stability and adjustability of each mechanism function of the equipment, and the reliability and safety of the instrument.

    4.Performance requirements of tablet press machine

    Select one or several physical test parameters, such as the shape, size and thickness of the pressed tablet, determine the appropriate rotational speed for physical production, and the quality of the pressed tablet meets the requirements of the finished product and national standards.

    The equipment conforms to the design parameters in the simulated production operation or the physical production operation, and there is no abnormal leakage of powder, liquid or metal chips and particles in the tablet pressing room.

    The operation and maintenance are simple, safe and reasonable, and the disassembly and assembly of mould, feeder and other parts are convenient.

    The equipment is easy to clean without dead angle and leakage.

    23.How does Rotary Tablet Press Machine control the weight of the tablets?

    The rotary tablet press machine uses the compression force to control the tablet weight during the compression process.

    It is gap between the rollers exerting pressure must remain constant to get the uniform tablet weight.

    And if the compression force does not remain constant,the quantity of the to be compressed granules in punch die cavity will be affected to be varies.

    And once the tablet thickness and hardness are set,a fixed amount of granules compressed between the punch at a fixed distance to generate the same amount of compression force on every tablet.

    Therefore,you will need to measure the compression force and compare it with the control parameters to know whether the tablet is within the weight tolerance.

    24.What specifications you need to provide to the supplier for customization?

    When purchasing a tablet press machine,you may have to choose a supplier who can design,customize and make dies for you to suit for your different production purpose.

    While at the same time,there is some information about your product that you need to provide to them,they are:

    1) Raw material

    The supplier may need to know the raw material to analyze its nature or fluidity to know if they are fall down from the hopper easily.

    2)Size,shape and yield capacity

    They will figure out if their machine can compress and which models will meeting with your requirements.

    25.What is the tablets coating process?

    After compression,all tablets need to be further proceeded to make it a real acceptable tablet,which referring to the coating process.

    The coating process is to cover up the bad taste ,then make it easy to swallow and protect the active ingredients inside to make it functionable.

    Tablets through the coating process will become smoother,more appealing and in a word,easier to be digested.

    tablets coating process

    Coated tablets

    There are coating machine for you make such coating process.

    26.What should be paid attention to when using a tablet press machine?

    You need to pay attention to the following aspects when using a tablet press machine:

    1.You shall first read the operation manual and operation procedures of the tablet press, and be familiar with its performance and operation methods of the control part.

    2.Before normal use, the die must be checked strictly, without any crack, edge missing, deformation and other defects. After installation, it should be tightened properly. If it is unqualified, you shall not use it to avoid damaging the equipment.

    3 As the granule  is an important factor related to the smoothly completion of the tablet pressing,so the granule quality should be controlled according to the process requirements, otherwise it will affect the tablet quality and the normal operation of the machine.

    4.As the tablet pressing speed will affect the tablet quality and the service life of the equipment,so generally,you shall make the tablet press speed slow to press difficult to form materials and large-diameter tablets, while fast for  easy to form small tablets.

    5.During idling, you should increase the filling volume to avoid the impact of the upper and lower punches on each other and damage to the shape of the stablets.

    6.Note that do not dismantle the machine parts on the equipment at will. In case of large vibration or abnormal sound during use, you should stop the machine for inspection immediately and use it after troubleshooting.

    7.It is recommended to clear the tablet pressing room at least once per shift. Some fine powder adhered to the punching rod, punching rod hole and middle die hole will lead to the inflexible rotation of plug punching and punching rod, which will affect the normal operation of the equipment.

    8.You shall regularly check and maintain the wearing parts, such as rail guide, pressing wheel, bridge and die, to prevent the damage of individual parts from affecting the whole machine.

    9.The tablet pressing speed shall be reduced as much as possible before shutdown.

    10.You shall refuel and maintain the equipment regularly according to the operation manual.

    27.Why there is tablets tolerance and how to deal with it?

    The excess of tablet weight means that the tablets tolerance exceeds the limit of Pharmacopoeia.

    Average weight Weight tolerance limit
    < 0.3g ±6 %
    ≥0.3g ±4 %

    Weight tolerance standard

    You will find the reasons and the solutions as below:

    1.Due to the uneven distribution of granules size and different flow rate during tablet pressing, that lead to the uneven filling up to the die holes.

    For example,if there is too much coarse granules, the tablet will be lighter, and if there are more fine granules, the tablet will be heavier.

    ★ Solution: You should make the granules evenly mixed sieve before compression.

    2.The fine powder adheres to the punch that may cause the lifting punch.

    ★ Solution: At this time,the lower punch will not rotate flexibly,so you will need to check in time,disassemble the die and clean the lower punch and the die holes.

    3.Due to the poor fluidity of the granules, the amount of granules flowing into the die hole sometimes is more and sometimes is less.

    ★ Solution: You will need to granulate again or add suitable fluid aids such as silica gel powder to improve the granules fluidity.

    4.Granules stratification.

    ★ Solution:You will need to reduce granules size difference.

    5.Use too large granules to make smaller tablets.

    ★ Solution:You shall select appropriate size of granules.

    6.The hopper is blocked, which often occurs in drugs with strong viscosity or humidity.

    ★ Solution: You should dredge the hopper, keep the tablet pressing environment dry, and add the flow aid properly.

    7.The punch is not in good coincidence with the die hole,for example,a lot of powder is leaked between the outer surface of the lower punch and the die hole, resulting in "astringent punching" and insufficient material filling.

    ★Solution:You need to replace the punch and die.

    8.There is variance in the length of the lower punch,that lead to uneven amount filling.

    ★Solution:You should make the length tolerance of the lower punch within ± 5 μ M.

    9.The damping force adjusted by the damping screw is not good.

    ★Solution: You shall re-adjust the damping screw.

    10.The filling track is worn or the filling mechanism is unstable.

    ★Solution:You shall replace or stabilize the filling track.

    28.How to deal with common problems of single punch tablet press machine?

    When you are using a single punch tablet press machine,you shall note below aspects including:

    1.The single punching machine can only operate in a certain direction, and can not be reversed to avoid damage to the parts.

    single punch tablet press machine-1

    AIPAK TDP-5 single punch tablet press machine

    2.When you are using a electrician driven single punch tablet press machine,the "handle" on the "big hand wheel" shall be pulled down to avoid personal injury during operation.

    3.You need to make the upper punch core rod in the rising position before starting the machine whether it is electrical or mechanical.

    As if you start the machine when the upper punch is in the down position, it will enter into the die just after the start. At this time, because the rotation speed of the machine has not been up, the inertia is small, it is easy to cause the situation of carjacking.

    4.You can adjust the belt tension through the two adjusting nuts on the electromechanical bottom plate,and note that if they are locked after adjustment.

    5.When there is no power supply, you shall remove the triangular belt to reduce resistance and wear. But do not remove the "big pulley", because the "big pulley" has the effect of flywheel labor-saving.

    6.Treatment method for carjacking

    (1) In case of car jacking during electric tablet pressing, turn off the power immediately to avoid burning the motor.

    (2) In case of serious jacking, it is necessary to loosen the connecting rod nut, turn the lower part of the upper punch rod anticlockwise with a wrench to make it rise to reduce the pressure, and then turn the big hand wheel to eject the tablet. Then re-adjust the tablet hardness.

    7.You will need to check the quality,weight,hardness and surface of the tablets frequently and adjusted in time.

    8.When using,if you find the granules still can not pressed into tablets when the pressure has been adjusted to a considerable extent or the tablets are too loose, delamination, debris, pockmarks, powder falling, etc.,

    You shall never adjust or increase the pressure which will damage the machine,but you should check the quality of the ingredients.

    29.How to solve common problems in tablet compression process?

    There will be several problems arise during the tablet compression process .

    You will find the solutions for them are:

    1.Capping

    Capping referring to the tablets fractures from its main body during the ejection or handling process.

    It is the most common problem when the air is constantly compressed.

    And the expansion of the tablets during the ejection will also lead to capping.

    At the time,you will need to reduce the tablet pressing speed,and clean the punches and dies,reset the punches and re-adjust the blades to prompt the ejection process.

    2.Sticking

    That’s when the granules is sticking on the tooling,you will find poor dried or lubricated tablets produced.

    Then you need to increase the compression pressure or decrease the turret speed.

    But when the issue is still on,you may have to re-polish the tooling of the tablet press machine.

    3.Cracking in tablets

    The little and fine cracking of the tablets may be the result from the quick expansion of the tablets.

    You may need to replace with flat punch faces as the cracking is usually seen when you are using the concave punch faces.

    Or you may choose to use a tapper die to solve this kind of problem.

    4.Chipping

    This phenomenon is the tablets break at the edge after compression or been finished products,which is also lead by the machine with incorrect parameters setting.

    Facing this issue,you may have to replace or polish the die to correct the parameter setting or polish the punch tips and the concavity of punch faces.

    5.Lamination

    Lamination refers to the tablets separates into two or various horizontal layers poor ejection or air-entrapment or too high turret speed.

    Then you have to use a tapered die or a quick decompression or lastly reduce the turret speed and the compression force.

    6.Double impression

    It is easy to understand that the double impression is lead by the lower punch not being fixed tightly which make it drop freely in a small distance that creating new markings on the tablets.

    It also could a result of not restricted to the upper punch that make it rotate again and make new imprints on the tablet.

    At this point,you may have to use device with anti-moving function to prevent this kind of issue.

    30.How to troubleshooting common problems of tablet press machine?

    The common faults of the mechanical part of the tablet press are easy to occur in the guide rail, the pressing wheel, the overload protection, the reducer and the die of the tablet press.

    Actually,there are many factors involved, including both the use factors and improper adjustment factors.

    So, it is necessary to clean the tablet press room regularly, and regularly check and maintain the working parts that are easy to wear.

    Now according to our experience accumulated in the actual use process, I will analyze and solve some common faults and maintenance methods.

    1 Worn of upper guide rail

    (1) It may be oil cut-off and improper oil filling to the upper punch, which causes the stamping punch and worn of the upper guide rail.

    To remedy this ,you will need to wipe the remaining oil on the upper punch surface with a clean rag, and then brush a little oil with a small brush, evenly apply it on the upper punch hat head and upper punch rod, so that the upper punching can rotate flexibly.

    However, the amount of oil should not be too much to prevent oil from penetrating into the powder and causing oil slick.

    (2) The oil quality is not good.

    Only engine oil can be selected for lubrication between the guide rail and punch rod. 30 gear oil or air compressor oil are recommended.

    (3) The pressing material is too fine and there is a lot of dust.

    It must be added lightly when feeding to avoid flying dust and abrasion of the upper guide rail.

    (4) If the pressing material is too wet and the upper guide rail is worn due to the phenomenon of product hanging or sticking, the material shall be re dried and lubricant added for rework.

    In addition, the process formula shall be improved to control the particle size distribution, fluidity and compressibility of the material.

    2 Worn of lower guide rail

    If the bridge plate of the lower guide rail is worn, you may have to repaired with oilston on the lighter,and the severely worn one can only be replaced.

    (1) If the pressing material is too thin or too damp,it will make the power punch hole or the lower punch skinned, which resulting in stamping,sticking and worn of the lower guide rail.

    Then you may need to clean the lower punch hole until it turns to move.

    And you shall also pay attention to whether there is any abnormal sound in the process of tablet pressing.

    When hearing the abnormal sound, you shall shut down the machine timely, wipe off the punching holes, the crusts on the punch or the tablet pressing materials for rework, so as to avoid serious undercutting, stamping.

    (2) The lower punch is not clean, which resulting in stamping .

    Then you may need to brush the lower punch hole.

    If the punch hole is skinned, the skinning must be cleaned with a scraper. Especially for products with high viscosity, the punch must be cleaned with alcohol to ensure that the punch can rotate flexibly.

    3 Pressing wheel

    The pressing wheel is a device to adjust the pressure of the tablet and increase the protection.

    Its common faults include the wearing of the pressing wheel, the lack of oil or the damage of the bearing of the pressing axle.

    If the outer circle of the pressure wheel is seriously worn,the tail resistance of the punch rod will be large, so you need to replace the pressure wheel.

    If the inner hole of the pressure wheel and the pressure axle are seriously worn, you shall also replace the pressure wheel or the pressure axle.

    Sometimes the fracture of the pressure axle is mainly due to the excessive bearing pressure At this time, you shall replace the pressure asle and adjust the material and re-adjust the pressure.

    In addition, you will have to lubricate and maintain of the bearing of the compressor shaft

    regularly and replaced in time in case of damage.

    4 Tablet press die

    Punch is an important part of tablet press. The common faults in use are: the punch rod is worn, which only can be replaced by a new one .

    Another problem is punch bending that mostly occurs on the small-diameter punch, which is mainly caused by excessive pressure.

    The punch bending will affect the weight difference of tablet, so replacement is necessary.

    5 Hopper is worn or installed improperly

    (1) When the bottom surface of hopper that close to the plane of turntable is worn,you will need to adjust the position of the hopper to make the gap between the bottom surface of the feeder and the working surface of the turntable is 0.05-0.1mm.

    (2)Both the upper punch stamping, lower punch breaking, lower punch blasting, upper punch hat head fracture and the part of the punch breaking is in the hopper not taken out in time will cause the hopper worn and even damage the machine.

    Then you shall make the pressure not be too large, the machine not be overloaded, and any abnormal situation must be found and handled in time.

    In the process of tablet pressing, if explosive punch or hopper worn is found, the punch shall be replaced in time.

    And when you have changed the hopper, the flat surface must be cleaned, and the cleaned powder and the blasted film must be isolated and treated.

    (3) The hopper is not installed properly, and there are granule particles on the flat of the turntable.

    At this time,you may have to adjust the screw positions on both sides of the hopper and the hopper positions to control the material flow.

    6 Tablet weight tolorance

    (1) The axial movement of the lifting rod causes inaccurate measurement and the variation of tablet weight.

    To remedy this,you shall check if the small turbine is worn and replace the worn parts in time.

    (2) It is the improper installation of the hopper that make the filling volume too small or not stable.Then you may need to adjust the screws on both sides of the hopper to increase the granules flow and be stable.

    (3) The lower punch stamping will also affect the filling amount and lead to the weight variation,then you may have to brush the lower punch hole or change the punch.

    (4) You may have to check whether the die meets the standard and change the unqualified punch.

    (5)The granules problem: the granules particle is too thick, and the tablet weight is unstable. Then you should weigh the tablet weight frequently, and re integrated the granules.

    7 Vibration of the whole machine

    (1) The shock pad compression screw is loose. T

    he shock pad needs to be installed correctly,you can check whether the compression screw is loose. If it is loose, tighten the nut.

    (2) The speed of tablet press is not correct. The speed should be reduced or increased.

    31.How to maintain the Single Punch Tablet Press Machine?

    You can maintain a single punch tablet press machine by the following ways:

    1.Testing by hand

    That is before the starting-up of the single punch tablet press machine ,you may have to test its working parts to make sure they are in good condition and if there is no problem,you can open it .

    2.Regularly cleaning of the machine

    After each use every day,you may have to take out the remaining powder and wipe all parts of the machine.

    If the machine is out of service for a long time, you must remove the die and clean the friction surfaces,coat it with anti rust oil and cover it with dust-proof clothes.

    While the die shall be wiped clean and then immersed in oil for preservation.

    3.Lubricating

    The lubrication of friction surface of all moving parts is of significant to ensure the normal operation of the machine and extend its service life.

    So, if the main moving parts are in short of oil, the machine will be damaged quickly and cannot be used.

    Therefore, before using the tablet press, you must lubricate all oil cups, oil holes and friction surfaces and cover the friction surfaces with oil film when running empty, then it can be put into operation.

    And for every future shift ,you shall also refuelon time, but not too much each time, so as to avoid spillage which will affect the cleaning and contaminate the tablets.

    4.Inspection of the machine

    You may have to check the parts regularly, at least twice a month.

    And before each shift, check whether each screw is loose, and pay attention to check frequently during the working process.

    If it is loose, tighten it immediately to avoid failure.

    In addition the  main parts that have screws are: punching up fastening nuts, fixing screws of die, lower punch fixing screws,connecting rod lock nuts, connecting rod pin set screws,lifting fork lock nuts, butterfly screws.

    Besides, it is necessary for you to check the quality of the die frequently.

    In case of any defect, crack or serious damage due to deformation, it is necessary to replace the die in time, so as to prevent the machine and tablet quality from being damaged due to failure.

    5.Measuring the Tooling System

    You need to regularly measure the tooling system of the tablet press machine to make sure that it keeps the original dimensions.

    If there is any change on the size,you will need to replace the tooling system,otherwise,it will affect your production efficiency.

    6.Storage of the machine

    You should store the machine in cool and dry condition to avoid corrosion of the metallic parts.

    32.How do you check the tablet quality?

    There are Pharmacopoeial and non-Pharmacopoeial tests for you to check the quality of the tablets.

    Tablet-quality-tests

    Tablet quality tests

    While the Pharmacopoeial tests are more official and standard tablet testing which include:

    1.Weight variantion checking

    2.Disintegration time checking

    3.Active ingredients checking

    4.Dissolution time checking

    And the non-Pharmacopoeial tests are non-official tests which include:

    • Tablet hardness checking
    • Tablet friability checking
    • Tablet tensile strength checking
    • Tablet Thickness checking
    • Tablet porosity checking

    33.How to deal with the pressed tablet can not be disintegrated within the prescribed time limit?

    Generally, the disintegrating medium is water or artificial gastric fluid, and its viscosity does not change much, so the four main factors that affect the penetration of disintegrating medium (water) into tablets are:

    • The number of capillaries
    • The pore diameter of capillaries
    • The surface tension of the liquid and the contact angle

    pressed tablet

    And the influencing factors of tablet disintegration include:

    1.The compressibility of raw and auxiliary materials

    It is reported that the raw and auxiliary materials with strong compressibility are prone to plastic deformation when compressed, and the disintegration of tablets is slow.

    And some experiments showed that the addition of starch in some tablets could increase the porosity of the tablets, significantly enhance the water absorption of the tablets and facilitate the rapid disintegration of the tablets.

    2.The hardness of granules

    When the hardness of granules is small, they are easy to be broken by pressure, and the tablets disintegrate slowly, on the contrary, when it is large, the tablets will disintegrate faster.

    3.The compression force

    In general, the greater the pressure, the slower the disintegration of tablets.

    Therefore, the pressure should be moderate, otherwise the tablet is too hard to disintegrate. However, the disintegration time of some tablets decreases with the increase of pressure, so they need to be treated differently.

    4.Lubricants and surfactants

    Hydrophobic lubricants commonly used in tablets may also seriously affect the wettability of tablets and accelerate the disintegration of tablets.

    When hydrophobic lubricant and particles are mixed for a long time and with a large mixing strength, the surface of granules is completely covered by hydrophobic lubricant.

    Therefore, the pore wall of the tablet has strong hydrophobicity, which can significantly prolong the disintegration time.

    strong hydrophobicity

    In addition, tablet disintegration is also affected by other excipients.

    For example, the influence of starch, starch can make insoluble or hydrophobic drugs disintegrate quickly, but it has poor effect with water-soluble drugs.

    Besides,the storage conditions of tablets are also very important.

    It is understood that the disintegration time of tablets is often prolonged after storage, that is,the temperature and humidity may also affect the disintegration.

    The tablets will slowly absorb moisture that make the disintegrating agent can not play its role, which result in the slow of the disintegration.

    While when the storage temperature of the sugar containing tablets is high or the tablets are wet, the disintegration will also be prolonged .

    34.What are the future prospects of Tablet Press Machine?

    As the production tool of tablet,the tablet press machine has made the tablets more compact, exquisite and aesthetic, convenient to take.

    Nowadays,with continuous reform and upgrading of tablet press technology, the tablet press machine industry has been moving towards to the direction of high-speed and high-yield.

    With the introduction of the new tablet press, the tablet production can reach 375 million tablets per year.

    However,the new technology requires the future tablet press machine should not only meet with the GMP requirements,but also have the functions of dust collection and cleaning, convenient and reliable operation, and necessary adjustment devices.

    Such as mechanical adjustment device, filling adjustment device, pressure adjustment device, speed adjustment device, sheet thickness adjustment device, etc.

    But also have reliable safety protection functions, such as pressure overload protection and current overload protection,high degree of automation control such as breaking and flushing protection, waste piece removal, fault alarm, automatic weighing and detection, etc.

    Aipak-tablet-press-machine-2

    AIPAK High speed rotary tablet press machine

    Besides,the design of tablet pressing room shall meet the requirements of airtight (isolated from the outside), pollution-free, easy observation, cleaning, convenient to assemble and disassemble .

    In fact,today tablet press machine with new stable tablet pressing system preloading, long compression time and small tablet weight variation, double impeller forced feeder,progressive sealed semi-automatic grease lubrication system ensures grease lubrication, special oil proof, dust-proof and noise proof design, surface of turntable covered with hardening layer to it not easy to worn are all can be prospected.

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