Pellets

Pellets are free flowing units, which are filled in capsules and formed by agglomeration technique. In agglomeration techniques, fine powder is taken, which is transformed into fine granules. These pellets offer several advantages such as multiple drug delivery in a single dose, masks taste of anxious drugs and thus improve patient compliance for drug administration over other dosage forms.

 

In addition, pharmaceutical pellets have varied application in pharmaceutical industries such as they improve aesthetic appearance of drugs and compatible for chemically incompatible drugs.

 

Pellets offer many additional features compared with conventional tablets. Aipak is able to offer a comprehensive range of pelletization processes and help you to select the procedure that best suits your needs.

 

That includes the fluid bed granulation machine,the dryer machine,the mixer machine,all of which work to make the pelletization process.

 

Pellets are typically varied between 500-1500 μm in size for pharmaceutical applications. It is of great interest over other similar techniques due to its uniformity of dose, less susceptibility of dose dumping, less friability etc. With the advent of these Aipak machines, drug loaded pellets have been widely investigated for its control release property in gastrointestinal tract.

Machines For Pellets

Capsule Filling Machine

NJP-200C Capsule Filling Machine

NJP-400C Capsule Filling Machine

NJP-800C Capsule Filling Machine

NJP-1200C Capsule Filling Machine

NJP-1200D Capsule Filling Machine

NJP-2500C Capsule Filling Machine

NJP-3800C Capsule Filling Machine

NJP-5500C Capsule Filling Machine

NJP-7500C Capsule Filling Machine

CGN-208D Capsule Filling Machine

CGN208-D1 Capsule Filling Machine

CGN208-D2 Capsule Filling Machine

CGN208-D3 Capsule Filling Machine

CGN-208S Capsule Filling Machine

TM-100 200 250 Capsule Making Machine

RJN Capsule making machine

Granulation Machine

HLSG Series High Shear Mixer Granulator

Model YK-160 Swing High Shear Mixer Granulator

FL Series Mixer Granulator Drier

KZL Series High Speed High Shear Mixer Granulator

Model ZL Rotating High Shear Mixer Granulator

GK Series Dry High Shear Mixer Granulator

GHL Series High Speed High Shear Mixer Granulator

Bin Mixer

SWH Series 3D Motion Bin Mixer

GHS High speed Bin Mixer

Model CH-VI Forced-Type Bin Mixer

CH Series Tanker Typed Bin Mixer

Model EYH Series Bin Mixer

WSH Series Tank Type Bin Mixer

CH Series Typed Bin Mixer (2011)

WLDH- Horizontal Ribbon Bin Mixer

DLH Series Cone Bin Mixer

Model W Series Taper-shaped Bin Mixer

CW series stirring type Bin Mixer

Model CH-V Series Bin Mixer

Bin Blender

HDT Series Bin Blender

DTH Series Post Bin Blender

HGD Series Lab Bin Blender

Dryer Machine

FG Series Fluid bed Dryer

LPG Series High-speed Pharmaceutical Dryer

DW Series Mesh-Belt Pharmaceutical Dryer

ZLG Series Vibration Fluidized Bed Dryer

SZG Series Double Cone Rotary Vacuum Dryer

GFG Efficient Boiling Pharmaceutical Dryer

FL300 Pharmaceutical Dryer

GF Series High Efficiency Fluidized Bed Drier

FZG,YZG squar and round static vacuum dryer

Model RXH Series Pharmaceutical Dryer

Videos For Pellets

How Capsule Filling Machine Fills Pellets

How Bin Blender Mixes Pellets

How Semi Automatic Capsule Filling Machine Fills Pellets

How NJP-200 Automatic Capsule Filling Machine Fills Pellets

How NJP-1200 Automatic Capsule Filling Machine Fills Pellets

How NJP-800 Automatic Capsule Filling Machine Fills Pellets

Frequently Asked Questions

Pellet materials for pharmaceutial purpose are:

  • Microcrystalline Cellulose
  • Tartaric acid (functional)
  • Isomalt
  • Sugar
  • Dibasic Calcium Phosphate
  • Polyols
  • Lactose-Starch
  • Lactose-Cellulose
  • Carnauba wax
  • Silica

Most pellet materials are seen to be neutral. They do not show mentionable influence on the drug dissolution characteristics. An exception are tartaric acid pellets (TAP). TAPs assist dissolution of weakly basic drugs by serving a localized acidic environment. A good summary is given in an overview article.

Several products contain pharmaceutical pellets. Pharamceutical pellets are found in multipartitular oral dosage forms:

  • Oral suspensions
  • Sachets / stick pack
  • ODT (oral desintegrating tablets)
  • MUPS (Multiple Unit Pellet Systems)
  • Fixed dose combinations
  • Capsules

Yes, definitely pharmaceutical pellets for paediatrics are useful. Advantages are:

  • flexible dosing units
  • homogeneous drug distribution
  • Reduces risks, such as dose dumping
  • high customer compliance of adolescents, children, infants, neonates and newborns

The main reason for specialized paediatric medicine are certain differences of the human body interaction with the drug formulation. For example, neonates and infants have increased stomach pH due to decreased acid secretion. Drug uptake and bioavailablity might therefore be different. Modified drug formulations are requested, which do not only consider a change in drug concentration, but also pay respect to dissolution profiles.

Mostly, pharmaceutical pellets for paediatrics are used in pellet technologies.

Main functionalities of starter pellets are:

  • serving as drug carrier in pharmaceutical formulations
  • suited for multi-particulate drug solutions
  • used for coating and layering with actives and excipients
  • allowing time-resolved release profiles

The overall expression for employing pellets in drug formulations is called pellet technologies. Some pellets, such as made of tartaric acid, serve additional functionalities.

The advantages of pellets in oral dosage forms compared to monolithic dosage forms are:

  • low variability of gastric emptying
  • lower dependency on nutrition state
  • low risk of localized high drug concentrations in the GI
  • reduced risk of sudden dose dumping
  • lower intra- and inter-individual variability
  • high control on time and place of drug delivery

Helpful Resources For Pellets

Wet Granulation Machine

Wet Granulation Machine:The Complete Buying Guide in 2021

Fluid Bed Dryer

Fluid Bed Dryer: Your Complete Solution Guide In 2021

Pellets banner

How To Choose The Best Capsule Filler As Your Requirement: The Complete Guide in 2021

Interested In Purchasing Your First Pellet Machines?

We have helpful resources to help answer common questions about pellet machines, the most popular machines, and a helpful guidebook for first-time buyers.

Scroll to Top