What Is CIP And SIP System?

Up until the mid of last century, a sealed system such as closed pipes, or processing equipment was cleaned by dismantling them. This process was invariably time-consuming, and laborious. Especially in industrial sectors like pharmaceuticals, food, and beverages, where you regularly require cleaning of a system.

Now, with innovation and advanced technology, the industrial sector is benefitted from the emergence of the Cleaning-In-Place (CIP) system and Sterilization-In-Place (SIP) system.

Fortunately, now you can achieve the cleaning process without the need of dismantling any system. CIP system and SIP systems are designed to clean the processing unit with 100% satisfactory outcomes.

CIP system

Table of Contents

I.What are the CIP system and SIP system?

II.What are the applications of the CIP system and SIP system?

Ⅲ.What is the Instrumentation of the CIP system and SIP system?

Ⅳ.What is the Structure of the CIP system and SIP system?

Ⅴ.What is the Cleaning Cycle of the CIP system and SIP system?

Ⅵ.What are the Advantages of the CIP System and SIP System?

Ⅶ.What are the differences between CIP system and SIP system?

Ⅷ.What are the Future Perspectives of the CIP system and SIP systems?


Ⅰ.What are the CIP system and SIP system?

CIP system-1


Clean in Place system is a whole set of actions that are performed with the purpose of cleaning all parts of equipment. The CIP system is built with the purpose of not disassembling the equipment for cleaning rather it is done while the equipment is intact. The cleaning solution is passed through the equipment as does the product pass.


Sterilization in Place or Steam in Place refers to the cleaning of processing systems mainly done through steam without disassembling the system. It is an extension of CIP system where the final step involves passing superheated steam through the equipment which makes the cleaning process more efficient and provides an extra measure to kill germs and avoid cross-contamination.

Ⅱ.What are the applications of the CIP system and SIP system?

CIP/SIP offers promising cleaning solutions for various industries including

Food Industry

For the food industry, CIP acts to clean the inner surfaces of food and beverage pipes, tanks, freezers, homogenizers, and mixers without disassembling them.

Food Industry

Dairy Industry

CIP systems are very important for the cleaning of dairy processing systems

For example, they are an integral part of yogurt processing line, ice cream processing line, and cheese processing systems

Dairy Industry


CIP provides an efficient cleaning method to remove residual yeast, spores, and any bacterial entities from the brewing system after each cycle without dismantling the system.


Pharmaceutical Industry

The pharmaceutical industry is highly benefitted y the CIP/SIP system where vessels and internal areas of pipes and equipment to make pharmaceutical products can be washed and cleaned while the machinery and system is intact.

Pharmaceutical Industry

SIP system is essential for applications where germ removal is critical for the example food industry and pharmaceutical industry.

Ⅲ.What is the Instrumentation of the CIP system and SIP system?

The key instruments of the CIP system are transmitters including temperature transmitters, flow transmitters, pressure transmitters, and turbidity sensors.

SIP system

Temperature Transmitters

Temperature transmitters play an important role as they function to monitor the temperature of systems supply and different solution tanks. There are probes installed in the lines that check if the temperature has reached a particular set point and send a signal to the heating system to regulate the temperature according to the requirement.

Temperature Transmitters

Flow Transmitters

Flow transmitters maintain a sufficient level of volume required to run a cycle in the wash and rinse tanks by keeping a check and sending signals to open or close a valve for water or chemical addition.

Flow Transmitters

Pressure Transmitters

Pressure transmitters have the critical function of checking the optimum flow of spray for controlling the wash and rinse steps.

Pressure Transmitters

Turbidity Sensors

These sensors make sure that all the chemical and soil has been removed and prevent wastage of water due to over rinsing.

Turbidity Sensors

Ⅳ.What is the Structure of the CIP system and SIP system?

For each product or processing system, the instrumentation is a little different as one thing cannot fit all. The basic procedure or making can be similar as each system has some common features but also contains particular features.

SIP system-1



The main body of the CIP system and SIP system mainly revolves around tanks. There can be a single tank or multiple up to four tanks depending upon the application. The material used is mostly stainless steel or for some quality, CIP and SIP systems utilize 316/316L as the manufacturing material.

Single Tank System

Single Tank System

These CIP systems and SIP system are based on a single tank. They are best suited for

  • small tasks
  • less frequently used systems
  • They need less space and are mobile
  • Are ideal for avoiding cross-contamination

Two-Tank System

Two-Tank System

Two tank system has particular features of

  • Easy mobility
  • One tank is designed for water and the other for a caustic solution.
  • Wash solutions can be recovered and reused hence cost-effective

It is however not best suited for processes having cross-contamination issues.

Three-Tank System

Three-Tank System

  • It offers more advanced and multi-cleaning options as compared to one-tank and two-tank systems.
  • Less time required
  • Wash solutions such as water and caustic solution can be recovered and reused.

Four-Tank System

Four-Tank System

  • Easy recovery of solutions for the reuse
  • Each tank is fitted with inlets and outlets and devices to monitor critical parameters like temperature and volume.

2.PUMPS- The Heart of the System

PUMPS- The Heart of the System

In CIP and SIP cleaning systems there are different types of pumps that hold great importance equivalent to the heart in the human body. Different types of pumps that are integral units of CIP and SIP  are


Units of Pump

Units of Pump

Supply Pump

The supply pump acts to provide enough pressure to create a turbulent flow to all the pipes, circuits, and spray devices in tanks. The pumps are made up of stainless steel and can generate different flows and pressures if coupled with a variable frequency drive (VFD).

Return Pump

The return pump is usually made up of removing or returns back the solution which has reached the processing system to CIP and SIP or to drain. The return pump should act faster compared to the supply pump.

Metering and Dosing Pumps

The metering and dosing pumps ensure an automatic and accurate supply of chemicals to the tanks. They also ensure the safety of employees via the safe addition of chemicals. For adding chemicals into the system peristaltic or air-operated pumps are usually used.



The tank cleaning cycles largely depend upon the spray devices. There are different types of spray devices chosen based on the tank size and the product being processed.

Static Spray Balls

Static Spray Balls

Static Spray Ball

They are stationary or static means staying in place inside the tank. They produce low flow and pressure and are made up of 316 stainless steel. Various hole patterns are available i.e 360° spray, 180° upward, or 180° downward spray.

Rotating Spray Balls

Rotating spray balls provide better cleaning due to enhanced exposure inside the tank. The rotating spray balls allow greater flow which creates a higher impact on the grubby tank surface.

Rotating Spray Balls

Rotating Spray Ball

Rotary Jet Heads

Rotary Jet Heads

Rotary Jet Heads-1

Rotary jet heads offer proper cleaning as they produce high impact streams of cleaning solution in all corners i.e. 360° while utilizing comparably less water.



Heating System

The appropriate temperature for the cleaning process is a critical aspect of any CIP system and SIP system. The high Temperature of the cleaning solution results in reduced cleaning time and cost in addition to efficiently removing the soil from the tank surface. Different strategies can be adopted for heat systems including


Plate & Frame Heat Exchanger

The compact design and low steam load requirement of the plate and frame heat exchanger make it a great choice for CIP systems

Shell & Tube Heat Exchanger

An inline heating system that is mostly used in the pharmaceutical and food industry is characterized by complete drainage of the product.

Direct Steam Injection

The purpose of these units is to introduce steam when the cleaning solution is added to the system.

Electric Heater

An electric heater is an expensive yet practical option for drying and cleaning purposes.

Ⅴ.What is the Cleaning Cycle of the CIP system and SIP system?

The cleaning cycle of the CIP system and SIP system refers to the programmed activities for complete cleaning of the processing system. Every system has its own custom events according to its specifications, but the overall cycle includes the following steps:

Cleaning Cycle of the CIP system


It’s the preparatory step where any residual product is pushed out and saved using a product recovery system.


It is a very important step in the wash cycle. After pushing out pre rinse is performed using deionized water or rinse solution which removes residual product and also removes sugars and fats by dissolving them.

Caustic Wash

For removing organic moieties like proteins and fats caustic wash is done which is actually done via a detergent.

Intermediate wash

After caustic wash another wash is done which is necessary to remove traces of detergent that guarantees proper washing.

Acid wash

Acid wash is an additional step depending upon the product as it removes minerals, protein left over and also maintains the pH of the system

Final Rinse

Final rinse is done with RO or DI water which ensures removal of any cleaning agents.

Air blow

To remove moisture created due to all cleaning and rinse methods air is blown which dries the system.

Sanitizing rinse

Additional step to kill germs before proceeding to the next cycle.

Ⅵ.What are the Advantages of CIP System and SIP System?

The pros of CIP method are as follows

  • Automatic or fast cleaning with reduced cycle times
  • Less water and detergent usage
  • Labor reduction
  • Enhanced safety protocols for workers and good handling of danger posing chemicals and compounds
  • Consistent and repeatable operation via automated CIP systems.
  • SIP combined with CIP provide extra measures of sterilization via steam hence advance and more critical cleaning of the processing systems.

Advantages of CIP System

The pros of CIP/SIP method are

  • Less time requires for each cleaning cycle
  • Less and controlled water usage
  • Need less detergent
  • Manual cleaning is eliminated

Ⅶ.What are the differences between CIP system and SIP system?

Cleaning in place Sterilization in place or steaming in place
Enables internal cleaning of sealed surfaces without dismantling. An extension of the CIP system process with additional sterilization.
A cleaning temperature is up to 100 °C. A critical hygiene process with pure steam temperature up to > 121 °C.
Removes all impurities Kills active microorganisms to ensure a significant sanitized environment.

Ⅷ.What is the Future Perspectives of the CIP system and SIP system?

The concept of lean manufacturing is getting prevalent in the 21st century which is based on lean thinking and minimizing waste and maximizing the value. With respect to CIP shorter cycles and quicker change overs can help the process.

The pharmaceutical industry will be greatly impacted by the less water usage approach trending worldwide. For CIP spray device technology is proposed to solve the excess water usage issue in future. CIP is the foremost water using facility thus adopting changes like spray device technology reduces water utilization.


CIP systems and SIP systems are an important aspect of cleaning the processing system while the system is intact and there is no need to disassemble the system. We hope ‘What is CIP system and SIP system?  has provided you enough information about the working and usage of CIP and SIP in pharmaceutical and other industries

Our manufactured machines are designed to combat harsh temperatures and chemicals required in CIP and SIP procedures that making them an ideal choice for pharma and foods applications.

Find us for more Help and Machine Guidance right now.

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